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Cetirizine, metabolite of hydroxyzine, is a potent and selective peripheral H1 receptor antagonist. Studies in vitro binding to receptors showed no measurable affinity for other receptors than the H1 receptor.
In association effects anti-H1, administered cetirizine 10 mg one dose or two times per day, inhibits the phase delayed recruitment of eosinophils in the level of the skin and connective tissue of the Atopic subjects after allergenic challenge tests.
Studies in healthy volunteers showed that cetirizine, at doses of 5 and 10 mg, strongly inhibits the evolution-papular reactions induced by high concentrations of histamine at the level of the skin. However the correlation of efficiency with these observations is not established.
In a study of 35 days conducted among children aged 5 to 12 years, was not observed decrease in the antihistamine cetirizine (inhibition of erythema and papules) effect. A discontinuation of treatment with cetirizine after repeated doses, the reactivity of the skin to the histamine is restored in 3 days.
In a controlled study versus placebo for six weeks conducted in 186 patients with allergic rhinitis and asthma light to moderate, cetirizine 10 mg once a day, has improved the symptoms of rhinitis without effect on lung function. This study highlights the safety of cetirizine in allergic patients with mild to moderate asthma.
In a controlled study versus placebo, cetirizine administered at a dose of 60 mg 7 days did not result in significant prolongation of the QT interval.
At the recommended dosage, improvement of quality of life has been demonstrated in patients treated with cetirizine with rhinitis allergic perennial and seasonal.
Hello
I would like to know the vanished pharmacy zyrtec my doctor replaced me him by of the AERIUS for about 10 years I took of zyrtec throughout the year which he already remplacait the Celestamine (I am very allergic to hay, grass etc and pollen and the rest of the year has various things in my house dust achariens etc) and with the treatment I had to when even let the zyrtec to the end of February celestamine beginning April because the zyrtec was not enough, today it gives me the Arius 5 mg while the zyrtec 10 mg, but I suffered several side effects is that there is not a generic or another drug with the same molecule under a name other than the Zyrtec
well I have problems with the arius of nose with swollen mucous membranes which I gene for sleeping is not very efficasse to me
Thanks for your answers
To replace the Zyrtec I took also throughout the year, my doctor I was careful of Virlix. The effect is almost identical and no side effect. Some are there mm more effect against food allergies as the Zyrtec. I am treated for pollen but also other ptites allergies pr

Zyrtec blocks histamine's action and makes the symptoms of an allergic reaction reduced.

Zyrtec is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.